Syntheses of Thiazolo-[5, 4-d]pyrimidine Derivatives and Related Compounds.
نویسندگان
چکیده
منابع مشابه
SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-ARYL-4- QUINOLINE- CARBOXAMIDE DERIVATIVES
Reaction of aryl methyl ketone with isatin in the presence of a base afforded 2- arylquinoline-4-carboxylic acid (3). Reaction of diazomethane with compound 3 yielded the ester 4. Compound 5 was prepared from the reaction of N, N'-dialkylethyl (or propyl) arnine with 4. Addition of hydrazine hydrate to compound 4a gave 2- (2- pyridyl) quinoline-4-carboxylic acid hydrazide (6). Reaction of l...
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Chiral 4-[(2-isopropyl-5-methylcyclohexyl)oxo]-4oxobutanoic acid reacts with substituted anilines to produce amides 1-6 in high yields. Resulted amides 1-6 were investigated for their antifungal and antibacterial activities. Compounds 2 (96.5%) against Aspergillus fumigatus and 6 (93.7%) against Helminthosporium sativum demonstrated excellent activities. However, compounds 3 (37.6%) against Bac...
متن کاملSyntheses, Antibacterial and Antifungal Activities of Substituted-Thiazolo-1,3,4-Thiadiazoles, 1,3,4-Oxadiazoles and 1,2,4-Thiazoles
Starting from readily available 2-substituted-4-methylthiazole-5-carboxylic acid hydrazide (1), The title compounds were prepared. The reaction of compound 1 (R=CH3) with formic acid yielded 1-(formyl)-2-(2,4-dimethylthiazole-5-carboxyl) hydrazine (2). Refluxing the latter with phosphorous pentasulfide in xylene afforded compound 3, the reaction of compound 2 with phosphorous pen...
متن کامل5'-methylaristeromycin and related derivatives.
The biological versatility of aristeromycin (carbocyclic adenosine) is limited by accompanying cytotoxicity caused ostensibly by the intracellular formation of its 5'-nucleotide derivatives. Aristeromycin derivatives that offered steric interference to this transformation at the C-5' center were sought. This paper describes the facile stereospecific synthesis, where necessary, of such C-5'-meth...
متن کاملAryne-mediated syntheses of structurally related acene derivatives.
Cycloaddition reactions of tetrakis(hexyloxy)-substituted 2,3-triphenylyne (2,3-didehydrotriphenylene) provide straightforward access to three new cata-condensed polyarenes characterized by the presence of 5, 8 and 11 fused benzene rings.
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1960
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.8.131